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Graves' disease is a
thyroid disorder characterized by goiter, exophthalmos,
"orange-peel" skin, and hyperthyroidism. It is caused by
an antibody-mediated auto-immune reaction, but the
trigger for this reaction is still unknown. It is the
most common cause of hyperthyroidism in the world, and
the most common cause of general thyroid enlargement in
developed countries.
In some parts of Europe the term Basedow’s disease or
Graves-Basedow disease is preferred to Graves' disease.
Graves disease is known for its enlarged thyroid and eye
problems. The ocular manifestations of Graves' disease
are more common in smokers and tend to worsen (or
develop for the first time) following radioiodine
treatment of the thyroid condition. Thus, they are not
caused by hyperthyroidism per se. This common
misperception may result from the fact that
hyperthyroidism from other causes may cause eyelid
retraction or eyelid lag (so-called hyperthyroid stare),
which can be confused with the general appearance of
proptosis or exophthalmos, despite the fact that the
globes do not actually protrude in other causes of
hyperthyroidism. Also, both conditions (globe protrusion
and hyperthyroid lid retraction) may exist at the same
time in the hyperthyroid patient with Graves' disease. |
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